반응 #77306

반응 방정식

1-(2,6-difluorophenyl)piperazine

8-(2-chloroethyl)-8-azaspiro[4.5]decane-7,9-dione

→

title compound

수율 26.4%

8-{2-[4-(2,6-Difluorophenyl)piperazino]ethyl}-8-azaspiro[4.5]decane-7,9-dione

수율 26.4%

반응 조건

후처리

1. 1
   온도was heated
2. 2
   기타The residue was purified by preparative HPLC (see Example 8 for conditions)
3. 3
   기타giving (

실험 절차

A mixture of 1-(2,6-difluorophenyl)piperazine (23.8 mg, 0.120 mmol) and 8-(2-chloroethyl)-8-azaspiro[4.5]decane-7,9-dione(20 mg, 0.087 mmol) was heated with stirring at 160° C. for 5 hours. The residue was purified by preparative HPLC (see Example 8 for conditions), giving (after removal of the solvent) the title compound as a pale yellow oil (8.9 mg, 0.023 mmol, 26%): ESI-MS m/z 392 (MH+).

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