반응 #77305

반응 방정식

1-(5-chloro-2-methylphenyl)piperazine

8-(2-chloroethyl)-8-azaspiro[4.5]decane-7,9-dione

→

title compound

수율 49.4%

8-{2-[4-(5-Chloro-2-methylphenyl)piperazino]ethyl}-8-azaspiro [4.5]decane-7,9-dione

수율 49.4%

반응 조건

후처리

1. 1
   온도was heated
2. 2
   기타The residue was purified by preparative HPLC (see Example 8 for conditions)
3. 3
   기타giving (

실험 절차

A mixture of 1-(5-chloro-2-methylphenyl)piperazine (20 mg, 0.095 mmol) and 8-(2-chloroethyl)-8-azaspiro[4.5]decane-7,9-dione(20 mg, 0.087 mmol) was heated with stirring at 160° C. for 5 hours. The residue was purified by preparative HPLC (see Example 8 for conditions), giving (after removal of the solvent) the title compound as a pale yellow oil (17.3 mg, 0.043 mmol, 49%): ESI-MS m/z 404 (MH+).

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