반응 #77304

반응 방정식

4-(5-fluoro-2-methoxyphenyl)piperidine

8-(2-chloroethyl)-8-azaspiro[4.5]decane-7,9-dione

→

title compound

수율 7.5%

8-{2-[4-(5-Fluoro-2-methoxyphenyl)piperidin-1-yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione

수율 7.5%

반응 조건

후처리

1. 1
   온도was heated
2. 2
   기타The residue was purified by preparative HPLC (see Example 8 for conditions)
3. 3
   기타giving (

실험 절차

A mixture of 4-(5-fluoro-2-methoxyphenyl)piperidine (20 mg, 0.096 mmol) and 8-(2-chloroethyl)-8-azaspiro[4.5]decane-7,9-dione(20 mg, 0.087 mmol) was heated with stirring at 165° C. for 1 hour. The residue was purified by preparative HPLC (see Example 8 for conditions), giving (after removal of the solvent) the title compound as a pale yellow oil (2.6 mg, 0.0065 mmol, 7%): ESI-MS m/z 403 (MH+).

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