반응 #77253

반응 방정식

3-amino-4-fluorophenyl 3-methyl-2-pyridyl ketone

sodium thiocyanate

acetic acid

bromine

acetic acid

→

title compound

수율 100.0%

4-Amino-5-fluoro-2-(3-methylpicolinoyl)phenyl thiocyanate

수율 100.0%

용매

water

반응 조건

후처리

1. 1
   여과The precipitate is filtered
2. 2
   기타dried

실험 절차

To a mixture of 3-amino-4-fluorophenyl 3-methyl-2-pyridyl ketone(4.20 g, 0.171 mol), sodium thiocyanate (4.19 g, 0.0517 mol) and glacial acetic acid is added a solution of bromine in acetic acid (2M, 12 ml, 0.0240 mol) over a one hour period. The resultant mixture is stirred one hour at room temperature and poured into cold water. The precipitate is filtered and dried to afford the title compound as a green solid (5.43 g, >100%) which is identified by NMR and mass spectral analysis.

출처