반응 #77249

반응 방정식

ammonium hydroxide

o-chlorophenyl 3-pyridyl ketone

sulfuric acid

nitric acid

sulfuric acid

→

title compound

수율 94.2%

3-(2-Chloro-5-nitrobenzoyl)pyridine

수율 94.2%

반응 조건

후처리

1. 1
   workup.ADDITIONis added dropwise
2. 2
   여과Filtration
3. 3
   기타drying

실험 절차

To a mixture of o-chlorophenyl 3-pyridyl ketone (10.0 g, 0.460 mol) and concentrated sulfuric acid at 0° C. is added dropwise a mixture of 90% nitric acid (2.40 ml) and concentrated sulfuric acid (6.0 ml). The resultant mixture is stirred one hour at 0° C., poured onto ice and neutralized with 30% ammonium hydroxide. Filtration and drying affords the title compound as a solid (11.4 g, 94.2%) which is identified by mass spectral analysis.

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