반응 #77237

반응 방정식

2-chloro-4-fluoro-5-nitrobenzoic acid

oxalyl chloride

→

title product

2-Chloro-4-fluoro-5-nitrobenzoyl chloride

용매

1,2-dichloroethane

반응 조건

후처리

1. 1
   온도refluxed for 3 hours
2. 2
   온도cooled
3. 3
   농축concentrated in vacuo

실험 절차

A mixture of 2-chloro-4-fluoro-5-nitrobenzoic acid (50.0 g, 0.228 mol) and N,N-dimethylformamide (5 drops) in 1,2-dichloroethane is treated dropwise with oxalyl chloride (30.8 mL, 0.353 mol), refluxed for 3 hours, cooled, and concentrated in vacuo to obtain the title product as an orange solid which is identified by NMR spectral analysis.

출처