반응 #7697

반응 방정식

2,4-dichloroquinazoline

3-amino-5-methylpyrazole

triethylamine

→

(2-chloroquinazolin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine

용매

ethanol

반응 조건

후처리

1. 1
   여과The pale yellow precipitate is then collected by filtration
2. 2
   세척washed with cold ethanol
3. 3
   기타dried under vacuum

실험 절차

To a solution of 2,4-dichloroquinazoline (12.69 g, 63 mmol) and 3-amino-5-methylpyrazole (6.18 g, 63 mmol) in ethanol (220 mL) is added triethylamine (8.13 mL, 63 mmol) and the reaction mixture is stirred for 3 hours at room temperature. The pale yellow precipitate is then collected by filtration, washed with cold ethanol and dried under vacuum to give (2-chloroquinazolin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.

출처