반응 #7694

반응 방정식

chloroacetonitrile

benzylpiperazine

→

N-benzyl-N′-cyanomethylpiperazine

용매

THF

Et3N

반응 조건

후처리

1. 1
   기타before quenched with saturated aqueous NaHCO3 (100 ml)
2. 2
   추출The aqueous phase was extracted with EtOAc (3×100 ml)
3. 3
   건조The combined organic layer was dried over MgSO4
4. 4
   농축concentrated to a residue, which
5. 5
   기타was used in the further reactions without any purification

실험 절차

An excess of chloroacetonitrile (7 ml) was added in to a solution of benzylpiperazine (2 g, 10.5 mmol) in THF (100 ml) and Et3N (10 ml). The reaction was stirred for 10 hours before quenched with saturated aqueous NaHCO3 (100 ml). The aqueous phase was extracted with EtOAc (3×100 ml). The combined organic layer was dried over MgSO4 and concentrated to a residue, which was used in the further reactions without any purification.

출처