반응 #7689

반응 방정식

4-fluorocinnamic acid

(S)-1-[3-(4-pyridin-2-yl-piperazin-1-yl)phenyl]ethylamine

EDC

triethylamine

→

title compound

수율 60.4%

(S)-3-(4-Fluorophenyl)-N-{1-[3-(4-pyridin-2-ylpiperazin-1-yl)phenyl]ethyl}-acrylamide

수율 60.4%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The reaction mixture was purified by flash chromatography over silica gel with ethyl acetate/hexanes (1:1)

실험 절차

A solution of 4-fluorocinnamic acid (17 mg, 0.1 mmol), (S)-1-[3-(4-pyridin-2-yl-piperazin-1-yl)phenyl]ethylamine (24 mg, 0.11 mmol), EDC (28 mg, 0.15 mmol), DMAP (12 mg, 0.1 mmol) and triethylamine (40 mg, 0.4 mmol) in dichloromethane (2 ml) was stirred at room temperature for 14 h. The reaction mixture was purified by flash chromatography over silica gel with ethyl acetate/hexanes (1:1) to give the title compound as a solid (26 mg, 60% yield).

출처