반응 #76830

반응 방정식

product

(R)-9-[4-(N-tert-Butoxycarbonyl-L-valyloxy)-2-(stearoyloxymethyl) butyl]guanine

trifluoroacetic acid

→

desired product

(R)-9-[2-(Stearoyloxymethyl)-4-(L-valyloxy)butyl]guanine

용매

Water

반응 조건

후처리

1. 1
   기타was then evaporated
2. 2
   기타to give an oil
3. 3
   기타evaporated twice
4. 4
   workup.DISSOLUTIONThe residue was once more dissolved in water (5 ml )
5. 5
   여과filtered
6. 6
   기타freeze-dried

실험 절차

The product from step b) (138 mg, 0.192 mmol) was cooled in an ice bath and trifluoroacetic acid (5 ml) was added. The solution was kept in the ice bath for 45 minutes and was then evaporated to give an oil. Water (0.5 to 1 ml) was added and evaporated twice. The residue was once more dissolved in water (5 ml ), filtered and freeze-dried to give 148 mg of the desired product as the bistrifluoracetate salt.

출처