반응 #76778

반응 방정식

3,3,3-trifluoro-2-oxo-1-propanal 1-(4-chlorophenylhydrazone)

ethyl diethylphosphonoacetate

→

2-(4-chlorophenyl)-5-trifluoromethylpyridazin-3-one

수율 52.9%

용매

triethylamine

반응 조건

후처리

1. 1
   workup.DISTILLATIONThe solvent was distilled out under reduced pressure

실험 절차

First, 2 g of 3,3,3-trifluoro-2-oxo-1-propanal 1-(4-chlorophenylhydrazone) and 2 g of ethyl diethylphosphonoacetate were mixed with 20 ml of triethylamine, and the reaction was allowed to proceed at 50° C. for 24 hours. The solvent was distilled out under reduced pressure, and the residue was subjected to column chromatography, which afforded 1.16 g of 2-(4-chlorophenyl)-5-trifluoromethylpyridazin-3-one (compound 1-332).

출처