반응 #76717

반응 방정식

2-amino-4-methoxycarbonylindan hydrochloride

4-chloro-5-methylthieno[2,3-d]pyrimidine

triethylamine

→

title compound

4-(4-Methoxycarbonylindan-2-yl)amino-5-methylthieno[2,3-d]pyrimidine

용매

ethanol

반응 조건

후처리

1. 1
   기타The product obtained
2. 2
   기타was purified by silica gel chromatography (hexane:ethyl acetate=2:1)

실험 절차

Using 2-(tert-butoxycarbonylamino)-4-methoxycarbonylindan (45 mg, 0.15 mmol) synthesized in the above Reference Production Example 7, 4N hydrochloric acid-dioxane (0.7 ml) and acetic acid (2.1 ml), a similar procedure to Production Example 213 was carried out to obtain 2-amino-4-methoxycarbonylindan hydrochloride. Then, using the 2-amino-4-methoxycarbonylindan hydrochloride, 4-chloro-5-methylthieno[2,3-d]pyrimidine (28 mg, 0.15 mmol), triethylamine (63 μl, 0.45 mmol), and ethanol (1 ml), a similar procedure to b) in Production Example 208 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=2:1) to obtain the title compound (15 mg, 0.044 mmol) having the following physical properties:

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