반응 #76715

반응 방정식

2-amino-4-methoxyindan

4-chloro-5-methylthieno[2,3-d]pyrimidine

triethylamine

→

title compound

수율 94.1%

4-(4-Methoxyindan-2-yl)amino-5-methylthieno[2,3-d]pyrimidine

수율 94.1%

용매

ethanol

반응 조건

후처리

1. 1
   기타The product obtained
2. 2
   기타was purified by silica gel chromatography (hexane:ethyl acetate=2:1)

실험 절차

Using 2-amino-4-methoxyindan (27 mg, 0.17 mmol) synthesized in the above b) in Reference Production Example 5, 4-chloro-5-methylthieno[2,3-d]pyrimidine (31 mg, 0.17 mmol), triethylamine (71 μl, 0.51 mmol), and ethanol (1.5 ml), a similar procedure to b) in Production Example 208 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=2:1) to obtain the title compound (50 mg, 0.16 mmol) having the following physical properties:

출처