반응 #76711

반응 방정식

N-benzyl-2-amino-5-indan carboxamide hydrochloride

triethylamine

4-chloro-5-methylthieno[2,3-d]pyrimidine

→

title compound

수율 63.6%

N-Benzyl-2-(5-methylthieno[2,3-d]pyrimidine-4-yl)amino-5-indan Carboxamide

수율 63.6%

용매

ethanol

반응 조건

후처리

1. 1
   기타A solid obtained
2. 2
   기타by purifying the product by silica gel chromatography (methylene chloride:ethanol=95:5)
3. 3
   세척was washed with ether

실험 절차

Using N-benzyl-2-amino-5-indan carboxamide hydrochloride (660 mg, 2.2 mmol), ethanol (19 ml), triethylamine (0.94 ml, 6.7 mmol), and 4-chloro-5-methylthieno[2,3-d]pyrimidine (410 mg, 2.2 mmol), a similar procedure to b) in Production Example 208 was carried out. A solid obtained by purifying the product by silica gel chromatography (methylene chloride:ethanol=95:5) was washed with ether to obtain the title compound (580 mg, 1.4 mmol) having the following physical properties:

출처