반응 #76703

반응 방정식

2-amino-5-[(E)-2-(4-methylphenyl)ethenyl]indan hydrochloride

triethylamine

4-chloro-5-methylthieno[2,3-d]pyrimidine

→

title compound

수율 58.3%

4-[5-[(E)-2-(4-Methylphenyl)ethenyl]indan-2-yl]amino-5-methylthieno[2,3-d]pyrimidine

수율 58.3%

용매

ethanol

반응 조건

후처리

1. 1
   기타obtained
2. 2
   기타was purified by silica gel chromatography (hexane:ethyl acetate=4:1)

실험 절차

Using 2-amino-5-[(E)-2-(4-methylphenyl)ethenyl]indan hydrochloride (16 mg, 0.06 mmol), ethanol (0.6 ml), triethylamine (50 μl, 0.36 mmol), and 4-chloro-5-methylthieno[2,3-d]pyrimidine (11 mg, 0.060 mmol), a similar procedure to b) in Production Example 208 was carried out The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=4:1) to obtain the title compound (14 mg, 0.035 mmol) having the following physical properties:

출처