반응 #76687

반응 방정식

7-chloro-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidine

2-aminoindan

triethylamine

→

title compound

수율 62.0%

2-Indanylamino-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidine

수율 62.0%

용매

methylene chloride

반응 조건

후처리

1. 1
   온도to reflux for 2 hours
2. 2
   기타The residue obtained
3. 3
   workup.DISTILLATIONby distilling off the solvent under reduced pressure
4. 4
   기타was purified by silica gel chromatography (hexane:ethyl acetate=1:4)

실험 절차

7-chloro-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidine (28 mg, 0.15 mmol) (see J. Med. Chem. 31, 454 (1988)), 2-aminoindan (66 mg, 0.50 mmol), and triethylamine (30 μl, 0.2 mmol) in dry methylene chloride (1 ml) were heated to reflux for 2 hours. The residue obtained by distilling off the solvent under reduced pressure was purified by silica gel chromatography (hexane:ethyl acetate=1:4) to obtain the title compound (26 mg, 0.093 mmol) having the following physical properties:

출처