반응 #76684

반응 방정식

4-cyano-5-ethoxymethyleneaminooxazole

2-aminoindan

→

title compound

수율 14.7%

7-(2-Indanylamino)oxazolo[5,4-d]pyrimidine

수율 14.7%

용매

ethanol

반응 조건

후처리

1. 1
   온도to reflux for 6.5 hours
2. 2
   기타The residue obtained
3. 3
   workup.DISTILLATIONby distilling off the solvent under reduced pressure
4. 4
   기타was purified by silica gel chromatography (methylene chloride:ethyl acetate=1:4)

실험 절차

4-cyano-5-ethoxymethyleneaminooxazole (240 mg, 1.5 mmol) (see, J. Am. Chem. Soc., 88, 3829 (1966), Bull. Chem. Soc. JAPAN, 43, 187 (1970), Bull. Chem. Soc. JAPAN, 43, 3909 (1970)) and 2-aminoindan (580 mg, 4.4 mmol) in dry ethanol (2 ml) were heated to reflux for 6.5 hours. The residue obtained by distilling off the solvent under reduced pressure was purified by silica gel chromatography (methylene chloride:ethyl acetate=1:4) to obtain the title compound (56 mg, 0.22 mmol) having the following physical properties:

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