반응 #76683

반응 방정식

2-aminoindan

4-hydroxypyrazolo[3,4-d]pyrimidine

phosphorus oxychloride

dimethylaniline

→

title compound

수율 56.0%

4-(2-Indanylamino)pyrazolo[3,4-d]pyrimidine

수율 56.0%

반응 조건

후처리

1. 1
   기타The product obtained
2. 2
   기타was purified by silica gel chromatography (hexane:ethyl acetate=5:2)

실험 절차

Using 4-hydroxypyrazolo[3,4-d]pyrimidine (140 mg, 1.0 mmol), phosphorus oxychloride (3.0 ml), and dimethylaniline (0.39 ml, 3.1 mmol), and then 2-aminoindan (400 mg, 3.0 mmol), a similar procedure to Production Example 194 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=5:2) to obtain the title compound (150 mg, 0.56 mmol) having the following physical properties:

출처