반응 #76678

반응 방정식

4-chloro-7-methylthieno[3,2-d]pyrimidine

2-aminoindan

→

title compound

수율 75.0%

4-(2-Indanylamino)-7-methylthieno[3,2-d]pyrimidine

수율 75.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도to reflux under an argon atmosphere for 1 hour
2. 2
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
3. 3
   기타the residue obtained
4. 4
   기타was purified by silica gel chromatography (hexane:ethyl acetate=1:1)

실험 절차

4-chloro-7-methylthieno[3,2-d]pyrimidine (74 mg, 0.40 mmol) and 2-aminoindan (270 mg, 2.0 mmol) in dry ethanol (3 ml) were heated to reflux under an argon atmosphere for 1 hour. The solvent was distilled off under reduced pressure and the residue obtained was purified by silica gel chromatography (hexane:ethyl acetate=1:1) to obtain the title compound (83 mg, 0.30 mmol) having the following physical properties:

출처