반응 #76677

반응 방정식

4-methylthiothieno[3,4-d]pyrimidine

2-aminoindan

→

title compound

수율 22.0%

4-(2-Indanylamino)thieno[3,4-d]pyrimidine

수율 22.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도to reflux under an argon atmosphere for 4 hours
2. 2
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
3. 3
   기타the residue obtained
4. 4
   기타was purified by silica gel chromatography (ethyl acetate:methanol=20:1)

실험 절차

4-methylthiothieno[3,4-d]pyrimidine (90 mg, 0.50 mmol) (see J. Heterocyclic Chem., 30, 509 (1993)) and 2-aminoindan (200 mg, 1.5 mmol) in dry ethanol (4 ml) were heated to reflux under an argon atmosphere for 4 hours. The solvent was distilled off under reduced pressure and the residue obtained was purified by silica gel chromatography (ethyl acetate:methanol=20:1) to obtain the title compound (30 mg, 0.11 mmol) having the following physical properties:

출처