반응 #76676

반응 방정식

4-chloro-5-methylthieno[2,3-d]pyrimidine

2-aminoindan

→

title compound

수율 100.0%

4-(2-Indanylamino)-5-methylthieno[2,3-d]pyrimidine

수율 100.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도to reflux under an argon atmosphere for 40 minutes
2. 2
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
3. 3
   기타the residue obtained
4. 4
   기타was purified by silica gel chromatography (hexane:ethyl acetate=5:1)

실험 절차

4-chloro-5-methylthieno[2,3-d]pyrimidine (92 mg, 0.50 mmol) (see J. Pharm. Soc. JAPAN, 109, 464 (1989)) and 2-aminoindan (330 mg, 2.5 mmol) in dry ethanol (1 ml) were heated to reflux under an argon atmosphere for 40 minutes. The solvent was distilled off under reduced pressure and the residue obtained was purified by silica gel chromatography (hexane:ethyl acetate=5:1) to obtain the title compound (140 mg, 0.50 mmol) having the following physical properties:

출처