반응 #76641

반응 방정식

1,4-phenylenediacetonitrile

ammonia

hydrogen

→

2-[4-(2-aminoethyl)phenyl]ethylamine

수율 98.0%

용매

methanol

반응 조건

후처리

1. 1
   기타Scheme I, step B′: Into a 250 mL reduction vessel were placed
2. 2
   여과filtered through a Celite® cake
3. 3
   농축the filtrate was concentrated under reduced vacuum

실험 절차

Scheme I, step B′: Into a 250 mL reduction vessel were placed 1,4-phenylenediacetonitrile (10 g, 64.02 mmol), liquid ammonia (25 mL), and W4-W6 range (medium range activity) Raney Nickel (1.25 g) in methanol (125 mL), and the mixture was heated at 100° C. under 300 psi (2068 kPa) of hydrogen gas for 10 hours. The reaction was cooled to room temperature and filtered through a Celite® cake and the filtrate was concentrated under reduced vacuum to give the intermediate title compound, 2-[4-(2-aminoethyl)phenyl]ethylamine, (10.3 g, 98%) as an oil. Electron spray M.S. 165 (M*+H).

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