반응 #76582
ord-4c34ab9f90044dc48d2e4e6aceb62655
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과The reaction mixture was filtered
- 2농축The filtrate was concentrated under vacuum
- 3기타to provide a green solid
- 4기타The resulting precipitate was isolated by filtration
- 5기타dried
실험 절차
7-Methoxy-3-nitroquinolin-4-ol (4.5 g, 20.4 mmol), methanol (250 mL), ammonium hydroxide (5 mL) and palladium on carbon (400 mg of 10%) were combined. The mixture was placed on a Parr apparatus under a hydrogen atmosphere at 40 psi (2.8 Kg/cm2) for 2 hrs. The reaction mixture was filtered. The filtrate was concentrated under vacuum to provide a green solid. This material was dissolved in methanol (20 mL) and then 1N hydrochloric acid in diethyl ether (75 mL) was added. The resulting precipitate was isolated by filtration and dried to provide 2.6 g of 3-amino-7-methoxyquinolin-4-ol hydrochloride as a pink solid.