반응 #76581

반응 방정식

7-methoxyquinolin-4-ol

Nitric acid

→

7-methoxy-3-nitroquinolin-4-ol

수율 62.1%

용매

propionic acid

반응 조건

후처리

1. 1
   온도was heated to reflux
2. 2
   온도The reaction mixture was refluxed for 2 hrs
3. 3
   기타The resulting precipitate was isolated by filtration
4. 4
   세척washed with cold ethanol
5. 5
   기타dried

실험 절차

A mixture of 7-methoxyquinolin-4-ol (5.0 g, 28.5 mmol) and propionic acid (50 mL) was heated to reflux. Nitric acid (3.2 mL of 70%, 50 mmol) was added dropwise over a period of 15 minutes. The reaction mixture was refluxed for 2 hrs and then allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, washed with cold ethanol followed by hexanes and then dried to provide 3.9 g of 7-methoxy-3-nitroquinolin-4-ol as a gray solid.

출처