반응 #76564
ord-e4885c4b8f684e60b82d19576330e135
반응 조건
온도
125°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도to cool to ambient temperature
- 2기타The resulting yellow precipitate was isolated by filtration
- 3세척rinsed with water
- 4기타with ethanol, and then recrystallized from N,N-dimethylformamide/water
실험 절차
Nitric acid (20 mL of 70%) was added to a hot (125° C.) solution of 7-fluoro-4-quinolinol (35 g, 214 mmol) in propionic acid (200 mL). The reaction mixture was stirred at 125° C. for about 1.5 hours and then allowed to cool to ambient temperature. The resulting yellow precipitate was isolated by filtration, rinsed with water and then with ethanol, and then recrystallized from N,N-dimethylformamide/water to provide 18 g of 7-fluoro-3-nitro-4-quinolinol.