반응 #76562

반응 방정식

ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate

→

7-fluoro-4-hydroxy-3-quinolinecarboxylic acid

수율 92.2%

용매

sodium hydroxide

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 3 hours during which time a solution
3. 3
   기타was obtained
4. 4
   여과it was filtered
5. 5
   여과through filter paper under vacuum
6. 6
   기타The resulting precipitate was collected
7. 7
   세척washed with water
8. 8
   기타dried

실험 절차

A suspension of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate (65 g, 0.28 mol) in 10% sodium hydroxide (250 mL) was heated at reflux for 3 hours during which time a solution was obtained. The reaction mixture was allowed to cool to ambient temperature and then it was filtered through filter paper under vacuum. The filtrate was acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with water and then dried to provide 53.5 g of 7-fluoro-4-hydroxy-3-quinolinecarboxylic acid as a white solid.

출처