반응 #76558

반응 방정식

Nitric acid

7-methyl-4-quinolinol

→

7-methyl-3-nitro-4-quinolinol

용매

propionic acid

반응 조건

후처리

1. 1
   기타The resulting precipitate was isolated by filtration
2. 2
   세척rinsed well with ethanol and water
3. 3
   기타dried

실험 절차

Nitric acid (6 mL of 70%) was slowly added to a hot (125° C.) solution of 7-methyl-4-quinolinol (10.5 g) in propionic acid (125 mL). The reaction mixture was stirred for about 1.5 hours and then it was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed well with ethanol and water and then dried to provide 6.9 g of 7-methyl-3-nitro-4-quinolinol as a pale yellow solid.

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