반응 #76455

반응 방정식

phthalazine

1-(4-Acetylaminophenyl)-7-methylthiophthalazine

methyl lithium

→

crude product

4-(4-Acetylaminophenyl)-1,2-dihydro-1-methyl-6-methylthiophthalazine

용매

THF

반응 조건

후처리

1. 1
   기타to quench
2. 2
   기타the reaction
3. 3
   추출The aqueous phase was extracted with DCM three times
4. 4
   건조The combined organic phase was dried over Na2SO4
5. 5
   기타Removal of the solvent

실험 절차

To a solution of the phthalazine 7 (1.2 g, 3.88 mmol) in THF (150 mL) was added methyl lithium (1.4 M, 11 mL) at 0° C. The resulting dark brown solution was stirred 2 hours. Ice water was added to quench the reaction. The aqueous phase was extracted with DCM three times. The combined organic phase was dried over Na2SO4. Removal of the solvent afforded the crude product, which was used directly for the next step.

출처