반응 #76451

반응 방정식

methyl 2-[2-(2-methylpropyl)benzothiazol-5-yl]propionate

5-Amino-4-chloro-3-ethylisothiazole

sodium methoxide

→

desired product

수율 65.0%

N-(4-chloro-3-ethylisothiazol-5-yl)-2-[2-(2-methylpropyl)benzothiazol-5-yl]propionamide

수율 65.0%

용매

tetrahydrofuran

tetrahydrofuran

ammonium chloride

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture stirred at room temperature for 1½ hours
2. 2
   추출extracted with dichloromethane
3. 3
   추출The organic extract
4. 4
   건조was dried over anhydrous magnesium sulfate
5. 5
   여과filtered
6. 6
   기타the filtrate evaporated in vacuo

실험 절차

5-Amino-4-chloro-3-ethylisothiazole (0.81 g, 0.005 mol) was added to a suspension of sodium methoxide (0.56 g, 0.010 mol) in tetrahydrofuran (5 ml) and the mixture stirred at room temperature for 25 minutes. A solution of methyl 2-[2-(2-methylpropyl)benzothiazol-5-yl]propionate (1.15 g, 0.004 mol) in tetrahydrofuran (4 ml) was added dropwise and the mixture stirred at room temperature for 1½ hours. The mixture was diluted with saturated aqueous ammonium chloride solution and extracted with dichloromethane. The organic extract was dried over anhydrous magnesium sulfate, filtered and the filtrate evaporated in vacuo. Trituration with diethyl ether gave the desired product (1.06 g).

출처