반응 #76409

반응 방정식

Benzoic acid 1-cyano-3-(4-methoxy-phenyl)-allyl ester

→

4-(4-methoxy-phenyl)-but-3-enenitrile

수율 57.0%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   온도cooling with a cold water bath
2. 2
   농축the mixture is concentrated by rotary evaporation
3. 3
   workup.STIRRINGstirred with 150 ml of water
4. 4
   workup.DISSOLUTIONThe polymer and organic materials are redissolved in CH2Cl2
5. 5
   세척washed with saturated sodium bicarbonate
6. 6
   기타to remove benzoic acid
7. 7
   기타Evaporation of the solvent and flash chromatography (150 g SiO2; hexane:ethyl acetate 80:20 v:v)

실험 절차

Benzoic acid 1-cyano-3-(4-methoxy-phenyl)-allyl ester (15 g; ca 0.050 mol) is dissolved in 100 ml of anhydrous tetrahydrofuran. Tetrakis(triphenylphosphine)palladium (0.88 g; 0.8 mmol) and 4.8 ml of poly(methylhydrosiloxane) (ca 80 meq; Aldrich) are added, and the mixture is stirred at ca 20° C., cooling with a cold water bath. After 3 h 30 min, the mixture is concentrated by rotary evaporation, stirred with 150 ml of water to hydrolyze the siloxane. The polymer and organic materials are redissolved in CH2Cl2 and washed with saturated sodium bicarbonate to remove benzoic acid. Evaporation of the solvent and flash chromatography (150 g SiO2; hexane:ethyl acetate 80:20 v:v) affords 4.9 g (57%) of pure 4-(4-methoxy-phenyl)-but-3-enenitrile, mp 75-76° C.

출처