반응 #76408

반응 방정식

potassium carbonate

Acetonitrile

4-Methoxycinnamaldehyde

acetonitrile

→

benzoic acid 1-cyano-3-(4-methoxyphenyl)-allyl ester

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONis added dropwise
2. 2
   기타the temperature between 0 and 2° C.
3. 3
   workup.WAITthe yellow mixture is further stirred 2 h at the same temperature
4. 4
   기타The phases are separated
5. 5
   세척the organic layer is washed with brine
6. 6
   건조dried over magnesium sulfate
7. 7
   기타evaporated

실험 절차

Acetonitrile (25 ml) is added to a solution of potassium carbonate (3.45 g; 0.025 mol) in 15 ml of water and the mixture is cooled to 0° C. 4-Methoxycinnamaldehyde (8.1 g; 0.05 mol) dissolved in acetonitrile (25 ml) is added dropwise under efficient stirring over 30 min, keeping the temperature between 0 and 2° C., and the yellow mixture is further stirred 2 h at the same temperature. The phases are separated, the organic layer is washed with brine, dried over magnesium sulfate, and evaporated. The crude benzoic acid 1-cyano-3-(4-methoxyphenyl)-allyl ester (15 g), obtained as a pale yellow oil, is used for the next step without further purification.

출처