반응 #76333

반응 방정식

water

3-hydroxybenzaldehyde

2-chloropyrimidine

K2CO3

→

3-(2-pyrimidinyl-oxy)benzaldehyde

수율 71.0%

용매

DMSO

반응 조건

후처리

1. 1
   추출extracted with Et2O
2. 2
   세척The organic layer was washed with 2.5 N NaOH, 1 N HCl, saturated NaHCO3 and brine
3. 3
   건조dried (MgSO4)
4. 4
   기타evaporated

실험 절차

Ex-605A) A slurry of 3-hydroxybenzaldehyde (1.22 g, 10 mmol), 2-chloropyrimidine (1.14 g, 10 mmol) and K2CO3 (1.65 g, 12 mmol) in DMSO (20 mL) was heated to 100° C. for 1 h. The cooled mixture was poured into water and extracted with Et2O. The organic layer was washed with 2.5 N NaOH, 1 N HCl, saturated NaHCO3 and brine, dried (MgSO4) and evaporated to yield 1.42 g (71%) of the desired 3-(2-pyrimidinyl-oxy)benzaldehyde product as a white solid which was used without further purification. 1H NMR (C6D6) δ7.12 (t, 1H), 7.54 (m, 1H), 7.66 (t, 1H), 7.78 (m, 1H), 7.83 (m, 1H), 8.64 (d, 2H), 10.05 (s, 1H).

출처