반응 #76323

반응 방정식

3-phenoxyaniline

1,1,1-trifluoro-2,3-epoxypropane

→

3-[(N-3-phenoxy-phenyl)amino]-1,1,1-trifluoro-2-propanol

수율 71.0%

반응 조건

후처리

1. 1
   기타was placed in a sealed tube
2. 2
   기타giving a dark solution
3. 3
   온도The stirred solution was heated 18 h
4. 4
   온도cooled
5. 5
   기타to give a dark oil
6. 6
   기타Purification by flash chromatography on silica gel eluting with dichloromethane

실험 절차

Ex-588B) A mixture of solid 3-phenoxyaniline (2.96 g, 16 mmol) and 1,1,1-trifluoro-2,3-epoxypropane (1.30 mL, 15.0 mmol) was placed in a sealed tube and heated to 100° C. giving a dark solution. The stirred solution was heated 18 h and cooled to give a dark oil. Purification by flash chromatography on silica gel eluting with dichloromethane gave 3.15 g (71%) of the desired 3-[(N-3-phenoxy-phenyl)amino]-1,1,1-trifluoro-2-propanol product as a colorless oil. Anal. calcd. for C15H14NO2F3.0.05 CH2Cl2: C, 59.92; H, 4.71; N, 4.64. Found: C, 59.92; H, 4.53; N, 4.73. HRMS calcd. 298.1055 [M+H]+, found: 298.1056.

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