반응 #76218

반응 방정식

Methyl 4-(3,4-dichlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolepropionate

potassium sodium (+)-tartrate tetrahydrate

sodium bis(2-methoxyethoxy)aluminum hydride

→

title compound

수율 74.1%

4-(3,4-Dichlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolepropanol

수율 74.1%

용매

toluene

toluene

toluene

반응 조건

후처리

1. 1
   workup.ADDITIONTo the obtained solution was added dropwise
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 1 h
3. 3
   여과The precipitated crystals were collected by filtration
4. 4
   세척washed successively with a 10% aqueous solution of potassium sodium (+)-tartrate tetrahydrate, pure water and isopropyl ether
5. 5
   기타air-dried

실험 절차

Methyl 4-(3,4-dichlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolepropionate (0.67 g) was dissolved in toluene (5 mL). To the obtained solution was added dropwise a mixture of a 70% solution (0.81 g) of sodium bis(2-methoxyethoxy)aluminum hydride in toluene and toluene (2 mL) at 0° C. and the mixture was stirred at 0° C. for 1 h. To the reaction mixture was carefully added a 10% aqueous solution (50 mL) of potassium sodium (+)-tartrate tetrahydrate and the mixture was stirred at room temperature for 1 h. The precipitated crystals were collected by filtration, washed successively with a 10% aqueous solution of potassium sodium (+)-tartrate tetrahydrate, pure water and isopropyl ether, and air-dried to give the title compound as crystals (0.46 g, 74%). Recrystallization from acetone-hexane gave pale-yellow prism crystals. melting point: 140-141° C.

출처