반응 #76210

반응 방정식

2-bromo-4′-trifluoromethylacetophenone

sodium formate

→

title compound

수율 80.1%

2-Hydroxy-4′-trifluoromethylacetophenone

수율 80.1%

용매

methanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux
3. 3
   농축The reaction mixture was concentrated
4. 4
   workup.ADDITIONpoured into water (500 mL)
5. 5
   여과The precipitated solid was collected by filtration
6. 6
   세척washed with water
7. 7
   기타air-dried

실험 절차

A mixture of 2-bromo-4′-trifluoromethylacetophenone (40.0 g), sodium formate (40.0 g) and methanol (200 mL) was heated under reflux and stirred for 6 h. The reaction mixture was concentrated and poured into water (500 mL). The precipitated solid was collected by filtration, washed with water and air-dried to give the title compound as crystals (24.5 g, 80%). melting point: 112-114° C.

출처