반응 #76195

반응 방정식

Carvedilol

→

III

2-(2-Methoxyphenoxy)ethylamine

Carvedilol

II

4-(oxiran-2-ylmethoxy)-9H-carbazole

용매

dioxane water

반응 조건

후처리

1. 1
   온도by heating the mixture
2. 2
   workup.WAITThe resulting solution was left at room temperature
3. 3
   workup.STIRRINGwithout stirring for about 15 h
4. 4
   여과the crystals were filtered through a buchner funnel
5. 5
   기타dried in a desiccator (connected to air pump) until constant weight

실험 절차

Carvedilol (4 g) was dissolved in 267 mL dioxane/water in the ratio 1:1.4 respectively by heating the mixture under stirring at 55° C. water bath. The resulting solution was left at room temperature without stirring for about 15 h then the crystals were filtered through a buchner funnel and dried in a desiccator (connected to air pump) until constant weight to yield Carvedilol Form III in a mixture with Carvedilol Form II.

출처