반응 #76194

반응 방정식

water

Carvedilol

→

III

2-(2-Methoxyphenoxy)ethylamine

Carvedilol

II

4-(oxiran-2-ylmethoxy)-9H-carbazole

용매

dioxane

반응 조건

후처리

1. 1
   workup.WAITThe resulting solution was left at room temperature
2. 2
   기타the crystalline precipitate which had formed
3. 3
   여과was filtered through a buchner funnel
4. 4
   기타dried in desiccator at room temperature (connected to air pump) until constant weight

실험 절차

Carvedilol (4 g) was dissolved in 76 mL dioxane at room temperature, and 110 mL of water were added in portions of about 10 mL to the stirred solution. The resulting solution was left at room temperature without stirring for about 15 h, then the crystalline precipitate which had formed was filtered through a buchner funnel and dried in desiccator at room temperature (connected to air pump) until constant weight to yield Carvedilol Form III in a mixture with Carvedilol Form II.

출처