반응 #76171

반응 방정식

ethyl 1-cyclopropyl-7-chloro-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylate

acetate

sulfuric acid

→

1-cyclopropyl-7-chloro-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

수율 88.1%

용매

water

반응 조건

후처리

1. 1
   온도The resulting mixture was cooled
2. 2
   여과filtered
3. 3
   기타The precipitate was re-crystallized from chloroform-ethanol

실험 절차

29.4 g of ethyl 1-cyclopropyl-7-chloro-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylate (0.088 mol), 160 ml of acetate acid, 100 ml of water and 18 ml of concentrated sulfuric acid were stirred at 100-110° C. for 40 minutes. The resulting mixture was cooled and filtered. The precipitate was re-crystallized from chloroform-ethanol to give 23.8 g of 1-cyclopropyl-7-chloro-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.0775 mol) in 88.1% yield, mp 288-293° C.

출처