반응 #7611

ord-35de8171a48847fc924677310cf7789a

반응 방정식

CC(=O)Cl
acetylchloride
Nc1ncccc1OCc1ccccc1
2-amino-3-benzyloxypyridine
[C-]#[N+]C(C)(C)CC(C)(C)C
1,1,3,3-tetramethylbutylisonitrile
CC=O
acetaldehyde
CC(=O)[n+]1c(C)c(NC(C)(C)CC(C)(C)C)n2cccc(OCc3ccccc3)c21.[Cl-]
1-acetyl-8-benzyloxy-2-methyl-3-(1,1,3,3-tetramethylbutylamino)imidazo[1,2-a]pyridin-1-ium chloride

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Example 9 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-3-benzyloxypyridine (0.1 M, DCM), 0.575 ml (0.115 mmol) 1,1,3,3-tetramethylbutylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) acetaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07087607B2uspto-grants-2006_08