반응 #7606

ord-3530e699346948b5a62efd1270abe4aa

반응 방정식

CC(=O)Cl
acetylchloride
Nc1nccs1
2-amino-thiazole
[C-]#[N+]C(C)(C)C
tert.-butylisonitrile
O=Cc1ccccc1
benzaldehyde
CC(=O)[n+]1c(-c2ccccc2)c(NC(C)(C)C)n2ccsc21.[Cl-]
7-acetyl-5-tert-butylamino-6-phenyl-imidazo[2,1-b]-thiazol-7-ium chloride

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Example 4 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-thiazole (0.1 M, DCM), 0.575 ml (0.115 mmol) tert.-butylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) benzaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07087607B2uspto-grants-2006_08