반응 #7600

반응 방정식

hydrogen chloride

4-chloro-6-methoxy-7-(3-pyrrolidinopropoxy)cinnoline hydrochloride

4-chloro-2-fluoroaniline

→

4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(3-pyrrolidinopropoxy)cinnoline hydrochloride

수율 73.6%

용매

2-pentanol

반응 조건

후처리

1. 1
   여과The solid was filtered off
2. 2
   세척washed with isopropanol
3. 3
   건조ether and dried under vacuum

실험 절차

A solution of 4-chloro-6-methoxy-7-(3-pyrrolidinopropoxy)cinnoline hydrochloride (130 mg, 0.32 mmol), (prepared as described for the starting material in Example 13), and 4-chloro-2-fluoroaniline (70 mg, 0.48 mmol), in 2-pentanol (4 ml) and 5M isopropanolic hydrogen chloride (1 ml) was heated at 120° C. for 2.5 hours. The solid was filtered off, washed with isopropanol and then ether and dried under vacuum to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(3-pyrrolidinopropoxy)cinnoline hydrochloride (110 mg, 66%).

출처