반응 #7599

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4-chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride

4-chloro-2-fluoroaniline

isopropanol

→

4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride

수율 106.3%

용매

2-pentanol

hydrogen chloride

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후처리

1. 1
   온도to cool
2. 2
   여과The resulting precipitate was collected by filtration
3. 3
   세척washed with ether
4. 4
   기타dried under vacuum

실험 절차

A solution of 4-chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride (150 mg, 0.36 mmol), (prepared as described for the starting material in Example 12), 4-chloro-2-fluoroaniline (77 mg, 0.53 mmol) in 2-pentanol (4 ml) and 5M isopropanolic hydrogen chloride (1 ml) was heated at 120° C. for 1 hour. The mixture was allowed to cool and isopropanol was added. The resulting precipitate was collected by filtration, washed with ether and dried under vacuum to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride (185 mg, 98%).

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