반응 #7598

반응 방정식

4,6-dichlorocinnoline

2-fluoro-5-hydroxy-4-methylaniline

→

6-chloro-4-(2-fluoro-5-hydroxy-4-methylanilino)cinnoline hydrochloride

수율 95.8%

용매

2-pentanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 45 minutes
3. 3
   온도After cooling the solid
4. 4
   여과was filtered off
5. 5
   세척washed with isopropanol

실험 절차

A solution of 4,6-dichlorocinnoline (200 mg, 1 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (169 mg, 1.2 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (4 ml) containing 7M isopropanolic hydrogen chloride (2 drops) was heated at reflux for 45 minutes. After cooling the solid was filtered off, washed with isopropanol followed by ether to give 6-chloro-4-(2-fluoro-5-hydroxy-4-methylanilino)cinnoline hydrochloride (326 mg, 95%).

출처