반응 #7597

반응 방정식

4-chloro-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline

2-fluoro-5-hydroxy-4-methylaniline

hydrogen chloride

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline

용매

2-pentanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 45 minutes
3. 3
   온도After cooling the solid
4. 4
   여과was filtered off
5. 5
   세척washed with isopropanol

실험 절차

A solution of 4-chloro-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline (130 mg, 0.41 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (70 mg, 0.5 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (3 ml) containing 5M hydrogen chloride in isopropanol (2 drops) was heated at reflux for 45 minutes. After cooling the solid was filtered off, washed with isopropanol followed by ether to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[2-(2-methoxyethoxy)ethoxy]cinnoline as an hydrochloride salt (159 mg, 88%).

출처