반응 #7595

반응 방정식

4-chloro-6,7-dimethoxycinnoline hydrochloride

2-fluoro-5-hydroxy-4-methylaniline

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-6,7-dimethoxycinnoline

용매

2-pentanol

반응 조건

후처리

1. 1
   기타(prepared
2. 2
   온도After cooling
3. 3
   여과the solid was filtered off
4. 4
   세척washed with isopropanol and ether
5. 5
   기타dried under vacuum

실험 절차

A solution of 4-chloro-6,7-dimethoxycinnoline hydrochloride (261 mg, 1 mmol), (prepared as described for the starting material in Example 1), and 2-fluoro-5-hydroxy-4-methylaniline (170 mg, 1.2 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (5 ml) was heated at 120° C. for 3 hours. After cooling, the solid was filtered off, washed with isopropanol and ether and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6,7-dimethoxycinnoline as an hydrochloride salt (301 mg, 82%).

출처