반응 #7588

반응 방정식

4-chloro-6-methoxy-7-(4-pyridylmethoxy)cinnoline hydrochloride

2-fluoro-5-hydroxy-4-methylaniline

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(4-pyridylmethoxy)cinnoline hydrochloride

수율 29.3%

용매

2-pentanol

반응 조건

후처리

1. 1
   기타(prepared
2. 2
   온도was heated
3. 3
   온도at reflux for 4 hours
4. 4
   여과After dilution with isopropanol the solid was filtered off
5. 5
   세척washed with isopropanol

실험 절차

A solution of 4-chloro-6-methoxy-7-(4-pyridylmethoxy)cinnoline hydrochloride (268 mg, 0.71 mmol), (prepared as described for the starting material in Example 10), and 2-fluoro-5-hydroxy-4-methylaniline, (109 mg, 0.77 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (6 ml) was heated at reflux for 4 hours. After dilution with isopropanol the solid was filtered off, washed with isopropanol followed by ether to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(4-pyridylmethoxy)cinnoline hydrochloride (92 mg, 29%).

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