반응 #7584

반응 방정식

4-chloro-6-methoxy-7-[(2-methylthiazol-4-yl)methoxy]cinnoline

2-fluoro-5-hydroxy-4-methylaniline

hydrogen chloride

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[(2-methylthiazol-4-yl)methoxy]cinnoline hydrochloride

수율 89.2%

용매

2-pentanol

isopropanol

반응 조건

후처리

1. 1
   기타(prepared
2. 2
   온도at reflux for 90 minutes
3. 3
   기타The solid obtained
4. 4
   여과was filtered off
5. 5
   세척washed with isopropanol

실험 절차

A suspension of 4-chloro-6-methoxy-7-[(2-methylthiazol-4-yl)methoxy]cinnoline (150 mg, 0.46 mmol) and 2-fluoro-5-hydroxy-4-methylaniline (78 mg, 0.56 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (3 ml) and a 5M solution of hydrogen chloride in isopropanol (105 μl) was heated at reflux for 90 minutes. The solid obtained was filtered off, washed with isopropanol followed by ether to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-[(2-methylthiazol-4-yl)methoxy]cinnoline hydrochloride as a pale yellow solid (190 mg, 82%).

출처