반응 #7583

반응 방정식

2-pentanol

4-chloro-6-methoxy-7-(3-pyrrolidinopropoxy)cinnoline hydrochloride

2-fluoro-5-hydroxy-4-methylaniline

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-methoxy-7-(3-pyrrolidinopropoxy)cinnoline

반응 조건

후처리

1. 1
   기타(prepared
2. 2
   온도was heated
3. 3
   온도at reflux for 1 hour
4. 4
   온도After cooling
5. 5
   여과the solid was filtered off
6. 6
   세척washed with isopropanol, ether
7. 7
   기타dried under vacuum

실험 절차

A solution of 4-chloro-6-methoxy-7-(3-pyrrolidinopropoxy)cinnoline hydrochloride (158 mg, 0.4 mmol), (prepared as described for the starting material in Example 13), and 2-fluoro-5-hydroxy-4-methylaniline (67 mg, 0.48 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (5 ml) was heated at reflux for 1 hour. After cooling, the solid was filtered off, washed with isopropanol, ether and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-methoxy-7-(3-pyrrolidinopropoxy)cinnoline as the hydrochloride salt (yellow solid, 55 mg, 27%).

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