반응 #7582

반응 방정식

4-chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride

hydrogen chloride

2-fluoro-5-hydroxy-4-methylaniline

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline

용매

2-pentanol

반응 조건

후처리

1. 1
   기타(prepared
2. 2
   온도was heated
3. 3
   온도at reflux for 30 minutes
4. 4
   온도After cooling
5. 5
   여과the solid was filtered off
6. 6
   세척washed with isopropanol, ether
7. 7
   기타dried under vacuum

실험 절차

A solution of 4-chloro-6-methoxy-7-(3-morpholinopropoxy)cinnoline hydrochloride (132 mg, 0.33 mmol), (prepared as described for the starting material in Example 12), and 2-fluoro-5-hydroxy-4-methylaniline (56 mg, 0.39 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (2.5 ml) containing 7M hydrogen chloride in isopropanol (9drops) was heated at reflux for 30 minutes. After cooling, the solid was filtered off, washed with isopropanol, ether and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxy-7-(3-morpholinopropoxy)cinnoline as an hydrochloride salt (yellow solid, 143 mg, 84%).

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