반응 #7580

반응 방정식

4-chloro-7-methoxycinnoline hydrochloride

3-hydroxy-4-methylaniline

→

4-(3-hydroxy-4methylanilino)-7-methoxycinnoline

용매

2-pentanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 2 hours
3. 3
   온도After cooling
4. 4
   여과the solid was filtered off
5. 5
   세척washed with isopropanol, ether
6. 6
   기타dried under vacuum

실험 절차

A suspension of 4-chloro-7-methoxycinnoline hydrochloride (196 mg, 0.85 mmol) and 3-hydroxy-4-methylaniline (123 mg, 1 mmol) in 2-pentanol (5 ml) was heated at reflux for 2 hours. After cooling, the solid was filtered off, washed with isopropanol, ether and dried under vacuum to give 4-(3-hydroxy-4methylanilino)-7-methoxycinnoline as the hydrochloride salt (yellow solid, 215 mg, 80%).

출처